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1

Machine learning and genetic algorithms in pharmaceutical development and manufacturing processes

Hoi-Ming Chi, Herbert Moskowitz, Okan K. Ersoy, Kemal Altinkemer, Peter F. Gavin, Bret E. Huff, Bernard A. Olsen

Journal:

Decision Support Systems

Year:

2009

Language:

english

File:

PDF, 797 KB

english, 2009

2

Strategy and Methodology Development for the Total Synthesis of Polyether Ionophore Antibiotics †

Faul, Margaret M., Huff, Bret E.

Journal:

Chemical Reviews

Year:

2000

Language:

english

File:

PDF, 4.52 MB

english, 2000

3

Protection of imidazoles as their β-trimethylsilylethoxymethyl (SEM) derivatives

Bruce H Lipshutz, Wayne Vaccaro, Bret Huff

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 210 KB

english, 1986

4

An Enantioselective Synthesis of Cis Perhydroisoquinoline LY235959

Hansen, Marvin M., Bertsch, Carl F., Harkness, Allen R., Huff, Bret E., Hutchison, Darrell R., Khau, Vien V., LeTourneau, Michael E., Martinelli, Michael J., Misner, Jerry W., Peterson, Barry C., Riec

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 149 KB

english, 1998

5

Encyclopedia of Reagents for Organic Synthesis || t -Butyldimethylchlorosilane

Year:

2001

Language:

english

File:

PDF, 155 KB

english, 2001

6

Mild alcohol methylation procedure for the synthesis of polyoxygenated natural products. Applications to the synthesis of lonomycin A

David A. Evans, Andrew M. Ratz, Bret E. Huff, George S. Sheppard

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 177 KB

english, 1994

7

Preparation of (±)-α-alkylated amino acid derivatives via imidazoles

Bruce H Lipshutz, Bret Huff, Wayne Vaccaro

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 256 KB

english, 1986

8

Evaluation of a New Macrocyclic Antibiotic as a Chiral Selector for Use in Capillary Electrophoresis

Sharp, V. Scott, Risley, Donald S., McCarthy, Sharon, Huff, Bret E., Strege, Mark A.

Journal:

Journal of Liquid Chromatography & Related Technologies

Year:

1997

Language:

english

File:

PDF, 437 KB

english, 1997

9

A new method for the preparation of tetrazoles from nitriles using trimethylsilylazide/trimethylaluminum

Bret E. Huff, Michael A. Staszak

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 250 KB

english, 1993

10

Synthesis of 2′,3′-dideoxy-3′-hydroxymethylcytidine; a unique antiviral nucleoside

Margaret M. Faul, Bret E. Huff, Steven E. Dunlap, Scott A. Frank, James E. Fritz, Stephen W. Kaldor, Michael E. LeTourneau, Michael A. Staszak, Jeffrey A. Ward, John A. Werner, Leonard L. Winneroski

Journal:

Year:

1997

Language:

english

File:

PDF, 1.55 MB

english, 1997

11

Lessons Learned in Creating Interoperable Fast Healthcare Interoperability Resources Profiles for Large-Scale Public Health Programs

Matney, Susan, Heale, Bret, Hasley, Steve, Decker, Emily, Frederiksen, Brittni, Davis, Nathan, Langford, Patrick, Ramey, Nadia, Huff, Stanley

Journal:

Applied Clinical Informatics

Year:

2019

Language:

english

File:

PDF, 228 KB

english, 2019

12

Metalations of imidazoles: (Poly)functionalization and conversions to imidazolones

Bruce H. Lipshutz, Bret Huff, William Hagen

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 236 KB

english, 1988

13

Stereochemistry of C-6 Nucleophilic Displacements on 1,1-Difluorocyclopropyldibenzosuberanyl Substrates. An Improved Synthesis of Multidrug Resistance Modulator LY335979 Trihydrochloride

Barnett, Charles J., Huff, Bret, Kobierski, Michael E., Letourneau, Michael, Wilson, Thomas M.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 139 KB

english, 2004

14

Oxazolophanes as masked cyclopeptide alkaloid equivalents: cyclic peptide chemistry without peptide couplings

Lipshutz, Bruce H., Huff, Bret E., McCarthy, Keith E., Mukarram, S. M. Jaweed, Siahaan, Teruna J., Vaccaro, Wayne D., Webb, Hugh, Falick, Arnold M., Miller, Todd A.

Journal:

Journal of the American Chemical Society

Year:

1990

Language:

english

File:

PDF, 1.49 MB

english, 1990

15

Diastereoselectivity in the heterogeneous hydrogenation reactions of phosphorous substituted olefins

Bret E. Huff, Vien V. Khau, Michael E. LeTourneau, Michael J. Martinelli, Naresh K. Nayyar, Barry C. Peterson

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 168 KB

english, 1997

16

Reductive Alkylation of Glycopeptide Antibiotics: Synthesis and Antibacterial Activity.

COOPER, ROBIN D. G., SNYDER, NANCY J., ZWEIFEL, MARK J., STASZAK, MICHAEL A., WILKIE, STEPHEN C., NICAS, THALIA I., MULLEN, DEBORAH L., BUTLER, THOMAS F., RODRIGUEZ, MICHAEL J., HUFF, BRET E., THOMPSO

Journal:

The Journal of Antibiotics

Year:

1996

Language:

english

File:

PDF, 469 KB

english, 1996

17

Lessons Learned in Creating Interoperable Fast Healthcare Interoperability Resources Profiles for Large-Scale Public Health Programs

Matney, Susan, Heale, Bret, Hasley, Steve, Decker, Emily, Frederiksen, Brittni, Davis, Nathan, Langford, Patrick, Ramey, Nadia, Huff, Stanley

Journal:

Applied Clinical Informatics

Year:

2019

File:

PDF, 228 KB

2019

18

Synthetic Approaches to Benzofuran Containing Insulin Sensitivity Enhancer Compounds for Treatment of Type II Diabetes

R Stille, John, E. Huff, Bret, L. Leffelman, Cindy, E. LeTourneau, Michael, A. Sullivan, Kevin, A. Ward, Jeffrey, R. Stille, John

Journal:

Year:

1997

Language:

english

File:

PDF, 754 KB

english, 1997

19

Total Synthesis of the Polyether Antibiotic Lonomycin A (Emericid)

Evans, David A., Ratz, Andrew M., Huff, Bret E., Sheppard, George S.

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 3.66 MB

english, 1995

20

Protection, metalation, and electrophilic substitution of 5-methyl tetrazole

Bret E. Huff, Michael E. LeTourneau, Michael A. Staszak, Jeffrey A. Ward

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 215 KB

english, 1996

21

ChemInform Abstract: Strategy and Methodology Development for the Total Synthesis of Polyether Ionorephore Antibiotics

Margaret M. Faul, Bret E. Huff

Journal:

Year:

2000

File:

PDF, 25 KB

2000

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